Miricorilant | GR antagonist | Probechem Biochemicals

Chemical Structure : Miricorilant

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Miricorilant (CORT118335)

货号: PC-25606Not For Human Use, Lab Use Only.

Miricorilant (CORT118335) is a potent, selective glucocorticoid receptor (GR) antagonist with binding Ki of 8 nM, selective over estrogen (ERα), androgen (AR) and progesterone (PR) receptors.

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生物&药学活性

Miricorilant (CORT118335) is a potent, selective glucocorticoid receptor (GR) antagonist with binding Ki of 8 nM, selective over estrogen (ERα), androgen (AR) and progesterone (PR) receptors.
Miricorilant (CORT118335) is efficacious when dosed orally in an olanzapine-induced weight gain model in rats.

物理化学性质&存储条件

分子量	428.46
分子式	C24H23F3N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-((1r,4r)-4-phenylcyclohexyl)-5-(3-(trifluoromethyl)benzyl)pyrimidine-2,4(1H,3H)-dione

参考文献

1. Hunt HJ, et al. J Clin Psychopharmacol. 2021 Nov-Dec 01;41(6):632-637.

2. Hunt HJ, et al. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7376-80.

Miricorilant (CORT118335)

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物理化学性质&存储条件

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Miricorilant (CORT118335)

生物&药学活性

物理化学性质&存储条件

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