Miransertib (ARQ-092, MK-7075) | pan-Akt inhibitor | Probechem Biochemicals

Chemical Structure : Miransertib

CAS No.: 1313881-70-7

加入收藏

Miransertib (ARQ092, MK-7075)

货号: PC-73209Not For Human Use, Lab Use Only.

Miransertib (ARQ-092, MK-7075) is a potent, selective and allosteric pan-Akt inhibitor with IC50 of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively.

规格	价格	库存
5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Miransertib (ARQ-092, MK-7075) is a potent, selective and allosteric pan-Akt inhibitor with IC50 of 2.7 nM, 14 nM and 8.1 nM for Akt1, Akt2, Akt3, respectively.
Miransertib (ARQ-092) also potently inhibits AKT1-E17K mutant inhibitor and phosphorylation of AKT.
Miransertib (ARQ-092) inhibited AKT activation not only by dephosphorylating the membrane-associated active form, but also by preventing the inactive form from localizing into plasma membrane.
Miransertib (ARQ-092) exhibited strong anti-tumor activity in endometrial PDX models harboring mutant AKT1-E17K and other tumor models.
ARQ 092 enhanced tumor inhibition of a common chemotherapeutic agent (paclitaxel).
Miransertib (ARQ-092) inhibited proliferation across multiple tumor types but is most potent in leukemia, breast, endometrial, and colorectal cancer cell lines.
Miransertib (ARQ-092) was more prevalent in cancer cell lines containing PIK3CA/PIK3R1 mutations compared to those with wt-PIK3CA/PIK3R1 or PTEN mutations.

物理化学性质&存储条件

分子量	432.531
分子式	C27H24N6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(3-(4-(1-aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine

参考文献

1. Yu Y, et al. PLoS One. 2015 Oct 15;10(10):e0140479.

2. Lapierre JM, et al. J Med Chem. 2016 Jul 14;59(13):6455-69.

Miransertib (ARQ092, MK-7075)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Miransertib (ARQ092, MK-7075)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.