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首页-小分子抑制剂&激动剂-NF-κB Pathway-TAK1-Minnelide
Minnelide

Chemical Structure : Minnelide

CAS No.: 1254702-87-8

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Minnelide (14-O-phosphonooxymethyltriptolide disodium salt)

货号: PC-70029Not For Human Use, Lab Use Only.

Minnelide is a water-soluble prodrug of triptolide that is highly effective in reducing pancreatic tumor growth and spread, and improving survival, induces and promotes apoptosis.

规格 价格 库存 数量
5 mg ￥1980 In stock
10 mg ￥3280 In stock
25 mg ￥5480 In stock
50 mg Get quote
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Minnelide is a water-soluble prodrug of triptolide that is highly effective in reducing pancreatic tumor growth and spread, and improving survival, induces and promotes apoptosis.
Minnelide efficiently downregulates both CD133(-) and CD133(+) population in the tumors, resulting in a 60% decrease in tumor volume.
Minnelide also is very effective as a therapeutic option against Castration Resistant Prostate Cancer (CRPC).

物理化学性质&存储条件

分子量 514.374
分子式 C21H25Na2O10P
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

sodium (((5bS,6aS,7aR,8R,8aS,9aS,9bS,10aS,10bS)-8a-isopropyl-10b-methyl-3-oxo-1,2,3,5,5b,6,6a,8,8a,9a,9b,10b-dodecahydrotris(oxireno)[2',3':4b,5;2'',3'':6,7;2''',3''':8a,9]phenanthro[1,2-c]furan-8-yl)oxy)methyl phosphate

参考文献

1. Chugh R, et al. Sci Transl Med. 2012 Oct 17;4(156):156ra139.

2. Banerjee S, et al. Clin Cancer Res. 2014 May 1;20(9):2388-99.

3. Isharwal S, et al. Prostate. 2017 May;77(6):584-596.

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