Minnelide | RNA polymerase II inhibitor | Probechem Biochemicals

Chemical Structure : Minnelide

CAS No.: 1254702-87-8

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Minnelide (14-O-phosphonooxymethyltriptolide disodium salt)

货号: PC-70029Not For Human Use, Lab Use Only.

Minnelide is a water-soluble prodrug of triptolide, an inhibitor of RNA polymerase II-mediated transcription, also is a selective inhibitor of CIC::DUX4 sarcoma (CDS).

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5 mg	￥1480	In stock
10 mg	￥2280	In stock
25 mg	￥3780	In stock
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100 mg		Get quote

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生物&药学活性

Minnelide is a water-soluble prodrug of triptolide, an inhibitor of RNA polymerase II-mediated transcription, also is a selective inhibitor of CIC::DUX4 sarcoma (CDS).
Minnelide acts through xeroderma pigmentosum type B to alter phosphorylation of RPB1, the largest subunit of RNA polymerase II, induces RPB1 degradation leading to apoptosis of CDS cells.
Minnelide is highly effective in reducing pancreatic tumor growth and spread, and improving survival, induces and promotes apoptosis.
Minnelide efficiently downregulates both CD133(-) and CD133(+) population in the tumors, resulting in a 60% decrease in tumor volume.
Minnelide also is very effective as a therapeutic option against Castration Resistant Prostate Cancer (CRPC).

物理化学性质&存储条件

分子量	514.374
分子式	C21H25Na2O10P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	sodium (((5bS,6aS,7aR,8R,8aS,9aS,9bS,10aS,10bS)-8a-isopropyl-10b-methyl-3-oxo-1,2,3,5,5b,6,6a,8,8a,9a,9b,10b-dodecahydrotris(oxireno)[2',3':4b,5;2'',3'':6,7;2''',3''':8a,9]phenanthro[1,2-c]furan-8-yl)oxy)methyl phosphate

参考文献

1. Chugh R, et al. Sci Transl Med. 2012 Oct 17;4(156):156ra139.

2. Banerjee S, et al. Clin Cancer Res. 2014 May 1;20(9):2388-99.

3. Isharwal S, et al. Prostate. 2017 May;77(6):584-596.

Minnelide (14-O-phosphonooxymethyltriptolide disodium salt)

生物&药学活性

物理化学性质&存储条件

参考文献

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Minnelide (14-O-phosphonooxymethyltriptolide disodium salt)

生物&药学活性

物理化学性质&存储条件

参考文献

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