Minesapride (DSP-6952)

Chemical Structure : Minesapride

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货号: PC-60521Not For Human Use, Lab Use Only.

Minesapride (DSP-6952) is a novel potent, selective, orally active 5-HT4 receptor partial agonist with Ki of 50-100 nM for human 5-HT4a/4b/4c.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Minesapride (DSP-6952) is a novel potent, selective, orally active 5-HT4 receptor partial agonist with Ki of 50-100 nM for human 5-HT4a/4b/4c.
Minesapride (DSP-6952) enhances gastric motility and causes colonic giant migrating contractions (GMCs) associated with defecation in conscious dogs, having ED50 value for inducing GMCs of 1.56 mg/kg.
Minesapride (DSP-6952) rapidly increases fecal wet weight without increasing fluid content in mice (1-10 mg/kg, p.o.).

物理化学性质&存储条件

分子量	454.95
分子式	C21H31ClN4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-amino-5-chloro-N-{[(2S)-4-{[1-(hydroxyacetyl)piperidin- 4-yl]methyl}morpholin-2-yl]methyl}-2-methoxybenzamide

参考文献

1. Mine Y, et al. Eur J Pharmacol. 2018 Feb 9;826:123-132.

2. Tsubouchi T, et al. Eur J Pharmacol. 2018 Mar 1;826:96-105.