Min-1

Chemical Structure : Min-1

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货号: PC-20704Not For Human Use, Lab Use Only.

Min-1 is small molecule that inhibits growth of Gram-positive bacteria by targeting the cell envelope, Min-1 is a novel inhibitor of bacterial growth, reduces cell size in Bacillus subtilis.

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生物&药学活性

Min-1 is small molecule that inhibits growth of Gram-positive bacteria by targeting the cell envelope, Min-1 is a novel inhibitor of bacterial growth, reduces cell size in Bacillus subtilis.
Min-1 inhibits growth of Gram-positive bacteria and reduces cell length of B. subtilis (MIC=31 uM, B. subtilis JH642 (LB)).
Min-1 disrupts coordination between growth and FtsZ ring assembly independent of known cell size mechanisms.
Min-1 activates the LiaRS stress response, which is sensitive to disruptions in the lipid II cycle and the cell membrane, and also compromises cell membrane integrity.

物理化学性质&存储条件

分子量	336.27
分子式	C16H11F3N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	OC1=CC=C(C2=NNC(C(F)(F)F)=C2OC3=CC=CC=C3)C(O)=C1

参考文献

1. Scott McAuley, et al. ACS Chem Biol. 2019 Apr 19;14(4):688-695.

Min-1

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Min-1

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物理化学性质&存储条件

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