Migrastatin | Cancer migration inhibitor | Probechem Biochemicals

Chemical Structure : Migrastatin

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Migrastatin ((+)-Migrastatin)

货号: PC-70248Not For Human Use, Lab Use Only.

Migrastatin is a biologically active natural product isolated from Streptomyces that has been shown to inhibit tumor cell migration.

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生物&药学活性

Migrastatin is a biologically active natural product isolated from Streptomyces that has been shown to inhibit tumor cell migration.
Migrastatin potently inhibits cancer metastasis in a murine breast tumor model, blocks Rac activation, lamellipodia formation, and cell migration, interferes with the invasion step of the metastatic process.

物理化学性质&存储条件

分子量	489.6
分子式	C27H39NO7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((S)-5-((2R,3Z,5R,6S,7S,8E,12E)-6-hydroxy-7-methoxy-3,5-dimethyl-14-oxooxacyclotetradeca-3,8,12-trien-2-yl)-4-oxohexyl)piperidine-2,6-dione

参考文献

1. Shan D, et al. Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3772-6.

2. Chen L, et al. Nature. 2010 Apr 15;464(7291):1062-6.

3. Lecomte N, et al. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15074-8.

Migrastatin ((+)-Migrastatin)

生物&药学活性

物理化学性质&存储条件

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Migrastatin ((+)-Migrastatin)

生物&药学活性

物理化学性质&存储条件

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