Microtubule inhibitor PP-13

Chemical Structure : Microtubule inhibitor PP-13

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货号: PC-72562Not For Human Use, Lab Use Only.

Microtubule inhibitor PP-13 is a novel microtubule-destabilizing agent, directly inhibits microtubule assembly by targeting the colchicine-binding site in β-tubulin.

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生物&药学活性

Microtubule inhibitor PP-13 is a novel microtubule-destabilizing agent, directly inhibits microtubule assembly by targeting the colchicine-binding site in β-tubulin.
PP-13 inhibits the growth of a wide range of cancer cell types, including targeted therapy-resistant and multidrug-resistant (MDR) cell lines (IC50=76-255 nM).
PP-13 overcomes the multidrug-resistant (MDR) phenotype in cancer cells, induces mitotic blockade in cancer cells, interferes with both mitotic microtubule organization and spindle pole integrity.
PP-13 induces cell prometaphase arrest then asymmetric division or direct apoptotic death.
PP-13 reduces tumour growth and metastasis invasion in vivo.

物理化学性质&存储条件

分子量	400.482
分子式	C24H24N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl 4-((4-(benzylamino)-6-methyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl)benzoate

参考文献

1. Pauline Gilson, et al. Sci Rep. 2017 Aug 31;7(1):10209.