Methylstat

Chemical Structure : Methylstat

CAS No.: 1310877-95-2

加入收藏

货号: PC-25582Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥1480	In stock
10 mg	￥2380	In stock
25 mg	￥3980	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Methylstat is a selective inhibitor of Jumonji C domain-containing histone demethylases (JHDMs) in cells, preferentially inhibits JMJD2A (H3K9me3 and H3K36me3 demethylase), JMJD2E (H3K9me3 demethylase) and JMJD3 (H3K27me3 demethylase).
Methylstat does not inhibit class I or class II HDACs, FAD-dependent demethylase LSD1, and weak activity against α-ketoglutarate-dependent hydroxylases such as prolyl hydroxylases PHD1-3.
Methylstat inhibited KYSE150 cell growth with IC50 of 5.1 uM.
Methylstat increased cellular levels of both H3K4me3 and H3K9me3 in KYSE150 cells with EC50 of 10.3 μM and 8.6 μM, respectively.
Methylstat (1-4 uM) prevents myogenesis through inhibition of H3K27me3-demethylase UTX in C2C12 cells.

物理化学性质&存储条件

分子量	505.57
分子式	C28H31N3O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-Butenoic acid, 4-[hydroxy[4-[[[4-[[[(1-naphthalenylamino)carbonyl]oxy]methyl]phenyl]methyl]amino]butyl]amino]-4-oxo-, methyl ester, (2E)-

参考文献

1. Luo X, et al. J Am Chem Soc. 2011 Jun 22;133(24):9451-6.

2. Yao H, et al. Pharmaceuticals (Basel). 2025 Sep 8;18(9):1344.

3. Schwarz FM, et al. Cancer Gene Ther. 2025 Mar;32(3):286-296.

Methylstat

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Methylstat

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.