Methyl Gerfelin | Glyoxalase I inhibitor | Probechem Biochemicals

Chemical Structure : Methyl Gerfelin

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Methyl Gerfelin (GLO1 inhibitor, Glyoxalase I inhibitor)

货号: PC-62074Not For Human Use, Lab Use Only.

Methyl Gerfelin (M-GFN) is an osteoclastogenesis inhibitor (IC50=2.8 uM) through the competitive inhibition of glyoxalase I (GLO1) with Ki of 0.23 uM.

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生物&药学活性

Methyl Gerfelin (M-GFN) is an osteoclastogenesis inhibitor (IC50=2.8 uM) through the competitive inhibition of glyoxalase I (GLO1) with Ki of 0.23 uM.
Methyl Gerfelin inhibits osteoclast differentiation, suppresses osteoclastogenesis with no influence on the phagocytic ability of BMMs.
Methyl Gerfelin significantly increases intracellular methylglyoxal (MG) levels in BMMs.
Methyl Gerfelin also inhibits P. falciparum GLO1.

物理化学性质&存储条件

分子量	304.298
分子式	C16H16O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 4-(2,3-dihydroxy-5-methylphenoxy)-2-hydroxy-6-methylbenzoate

参考文献

1. Kawatani M, et al. Proc Natl Acad Sci U S A. 2008 Aug 19;105(33):11691-6.

2. Urscher M, et al. Mol Microbiol. 2010 Apr;76(1):92-103.

3. Kanoh N, et al. Bioconjug Chem. 2013 Jan 16;24(1):44-52.

Methyl Gerfelin (GLO1 inhibitor, Glyoxalase I inhibitor)

生物&药学活性

物理化学性质&存储条件

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Methyl Gerfelin (GLO1 inhibitor, Glyoxalase I inhibitor)

生物&药学活性

物理化学性质&存储条件

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