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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Eukaryotic Initiation Factor (eIF)-Metarrestin
Metarrestin

Chemical Structure : Metarrestin

CAS No.: 1443414-10-5

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Metarrestin (ML246, ML 246)

货号: PC-35083Not For Human Use, Lab Use Only.

Metarrestin (ML246) is a specific inhibitor of perinuclear compartment (PNC), disrupts PNCs in PC3M-GFP-PTB cells with IC50 of 0.39 uM, specifically binds eEF1A2.

规格 价格 库存 数量
5 mg ￥980 In stock
10 mg ￥1480 In stock
25 mg ￥2580 In stock
50 mg ￥4280 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Metarrestin (ML246) is a specific inhibitor of perinuclear compartment (PNC), disrupts PNCs in PC3M-GFP-PTB cells with IC50 of 0.39 uM, specifically binds eEF1A2.
Metarrestin (ML246) reduces PNC prevalence in different human cancer cell lines at 1 uM (IC100 for PC3M cells) for 24 hours.
Metarrestin (ML246) disrupts the nucleolar structure and inhibits RNA polymerase (Pol) I transcription, by interacting with the translation elongation factor eEF1A2inhibits cancer cell invasion in vitro, suppresses metastatic development in three mouse models of human cancer, and extends survival of mice in a metastatic pancreatic cancer xenograft model with no organ toxicity or discernable adverse effects.

物理化学性质&存储条件

分子量 474.608
分子式 C31H30N4O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Trans-4-(7-benzyl-4-imino-5,6-diphenyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-3-yl) cyclohexanol

参考文献

1. Frankowski KJ, et al. Sci Transl Med. 2018 May 16;10(441). pii: eaap8307.

2. Frankowski K, et al. Discovery and Development of Small Molecules That Reduce PNC Prevalence.Probe Reports from the NIH Molecular Libraries Program [Internet].

3. Rocchi A, et al. PLoS Genet. 2017 Aug 14;13(8):e1006962.

4. Kuramoto K, et al. Autophagy. 2016 Sep;12(9):1460-71.

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