Mesendogen | TRPM6 inhibitor | Probechem Biochemicals

Chemical Structure : Mesendogen

CAS No.: 864716-85-8

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Mesendogen (Compound 6528694)

货号: PC-38603Not For Human Use, Lab Use Only.

Mesendogen (Compound 6528694, MEG) is a small molecule inhibitor of TRPM6 channel, promotes mesoderm and definitive endoderm differentiation of human embryonic stem cells (hESCs) through alteration of magnesium homeostasis.

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5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg	￥4280	In stock
100 mg		Get quote

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生物&药学活性

Mesendogen (Compound 6528694, MEG) is a small molecule inhibitor of TRPM6 channel, promotes mesoderm and definitive endoderm differentiation of human embryonic stem cells (hESCs) through alteration of magnesium homeostasis.
Mesendogen induces nearly homogeneous mesoderm differentiation in combination with the A-BVF condition, enhances mesoderm differentiation of hiPSCs and of variations of mesoderm induction conditions.
Mesendogen functions at the onset of mesendoderm differentiation but shows no effect on Nodal and Wnt signaling.
MEG functions by inhibiting cellular magnesium uptake.

物理化学性质&存储条件

分子量	400.844
分子式	C18H16ClF3N2OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((2-chloro-5-(trifluoromethyl)phenyl)carbamothioyl)-4-isopropylbenzamide

参考文献

1. Yijie Geng, et al. Heliyon. 2015 Dec 1;1(4):e00046.

Mesendogen (Compound 6528694)

生物&药学活性

物理化学性质&存储条件

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Mesendogen (Compound 6528694)

生物&药学活性

物理化学性质&存储条件

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