Merimepodib | IMPDH inhibitor | Probechem Biochemicals

Chemical Structure : Merimepodib

CAS No.: 198821-22-6

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Merimepodib (VI-21497, VX-497, MMPD)

货号: PC-35011Not For Human Use, Lab Use Only.

Merimepodib (VX-497, VI-21497, MMPD) is a potent, selective, reversible, uncompetitive IMPDH inhibitor with broad-spectrum antiviral activity.

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5 mg	￥1280	In stock
10 mg	￥1880	In stock
25 mg	￥3280	In stock
50 mg	￥5280	In stock
100 mg		Get quote

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生物&药学活性

Merimepodib (VX-497, VI-21497, MMPD) is a potent, selective, reversible, uncompetitive IMPDH inhibitor with broad-spectrum antiviral activity.
Merimepodib inhibits HBV, HCMV, RSV and HSV-1 with IC50 of 0.4, 0.8, 1.1 and 6.3 uM, also inhibits BVDV, VEEV, Coxsackie B3 and Dengue virus with IC50 at low uM level.
Merimepodib is 17- to 186-fold more potent than ribavirin against HBV, HCMV, RSV, HSV-1, parainfluenza-3 virus, EMCV, and VEEV infections in cultured cells, also demonstrates additivity when coapplied with IFN-alpha.

物理化学性质&存储条件

分子量	452.467
分子式	C23H24N4O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-tetrahydrofuran-3-yl (3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)benzyl)carbamate

参考文献

1. Markland W, et al. Antimicrob Agents Chemother. 2000 Apr;44(4):859-66.

2. Tong X, et al. Antiviral Res. 2018 Jan;149:34-40. doi: 10.1016/j.antiviral.2017.11.004.

3. Beevers RE, et al. Bioorg Med Chem Lett. 2006 May 1;16(9):2535-8.

4. Decker CJ, et al. Drugs Exp Clin Res. 2001;27(3):89-95.

Merimepodib (VI-21497, VX-497, MMPD)

生物&药学活性

物理化学性质&存储条件

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Merimepodib (VI-21497, VX-497, MMPD)

生物&药学活性

物理化学性质&存储条件

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