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首页-小分子抑制剂&激动剂-NF-κB Pathway-MALT1-Mepazine
Mepazine

Chemical Structure : Mepazine

CAS No.: 2975-36-2

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Mepazine (Pecazine)

货号: PC-49478Not For Human Use, Lab Use Only.

Mepazine is a potent, selective MALT1 paracaspase inhibitor with IC50 of 0.83 uM.

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25 mg ￥980 In stock
50 mg ￥1480 In stock
100 mg ￥2380 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Mepazine is a potent, selective MALT1 paracaspase inhibitor with IC50 of 0.83 uM.
Mepazine (5 uM) inhibited cellular MALT1 cleavage activity and significantly reduced IL-2 induction in T cells, impaired MALT1-mediated T cell activation.
Mepazine inhibited anti-apoptotic NF-κB signaling and elicit toxic effects selectively on MALT1-dependent ABC-DLBCL cells in vitro and in vivo.

物理化学性质&存储条件

分子量 346.92
分子式 C19H23ClN2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

10-[(1-methyl-3-piperidyl)methyl]-10H-phenothiazine monohydrochloride

参考文献

1. Nagel D, et al. Cancer Cell. 2012 Dec 11;22(6):825-37.

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