Mcl-1-Puma inhibitor 8 |CAS:678158-55-9 Probechem Biochemicals

Chemical Structure : Mcl-1-Puma inhibitor 8

CAS No.: 678158-55-9

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Mcl-1-Puma inhibitor 8 (CLZ-8)

货号: PC-62551Not For Human Use, Lab Use Only.

Mcl-1-Puma inhibitor 8 is a small-molecule dual-acting compound that targets the apoptotic Mcl-1-PUMA interface with Ki of 0.3 uM (Mcl-1, FPA), reduces multiple cancer cells and inhibits PUMA-mediated apoptosis.

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10 mg	￥1880	In stock
25 mg	￥2980	In stock
50 mg	￥4580	In stock
100 mg		Get quote

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生物&药学活性

Mcl-1-Puma inhibitor 8 (CLZ-8) is a small-molecule dual-acting compound that targets the apoptotic Mcl-1-PUMA interface with Ki of 0.3 uM (Mcl-1, FPA), reduces multiple cancer cells and inhibits PUMA-mediated apoptosis.
Mcl-1-Puma inhibitor 8 is a useful chemical probe to achieve safer cancer therapies by modulating Mcl-1-PUMA interaction.

物理化学性质&存储条件

分子量	393.505
分子式	C22H23N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-([1,1'-biphenyl]-4-ylmethylene)-2-(4-(2-hydroxyethyl)piperazin-1-yl)thiazol-4(5H)-one

参考文献

1. Liu J, et al. Oncotarget. 2017 Apr 20;8(33):54236-54242.

Mcl-1-Puma inhibitor 8 (CLZ-8)

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物理化学性质&存储条件

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Mcl-1-Puma inhibitor 8 (CLZ-8)

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物理化学性质&存储条件

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