Maxadilan

Chemical Structure : Maxadilan

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货号: PC-27326Not For Human Use, Lab Use Only.

Maxadilan is a potent, specific PACAP-type I receptor (PAC1) agonist, a potent vasodilator peptide and immunomodulator.

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生物&药学活性

Maxadilan is a potent, specific PACAP-type I receptor (PAC1) agonist, a potent vasodilator peptide and immunomodulator.
Maxadilan induces the accumulation of cAMP only in PACAP type I receptor expressing cells.
Maxadilan binds specifically to the PACAP type I receptor and competes spatially with the binding of PACAP and vice versa.

物理化学性质&存储条件

分子量	6865.72
分子式	C291H466N86O94S6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Cys-Asp-Ala-Thr-Cys-Gln-Phe-Arg-Lys-Ala-Ile-Asp-Asp-Cys-Gln-Lys-Gln-Ala-His-His-Ser-Asn-Val-Leu-Gln-Thr-Ser-Val-Gln-Thr-Thr-Ala-Thr-Phe-Thr-Ser-Met-Asp-Thr-Ser-Gln-Leu-Pro-Gly-Asn-Ser-Val-Phe-Lys-Glu-Cys-Met-Lys-Gln-Lys-Lys-Lys-Glu-Phe-Lys-Ala-NH2 (Disulfide bridge:Cys1-Cys5, Cys14-Cys51)

参考文献

1. Lerner EA, et al. J Biol Chem. 1991 Jun 15;266(17):11234-6.

2. Tatsuno I, et al. Brain Res. 2001 Jan 19;889(1-2):138-48.

3. Bozza M, et al. Eur J Immunol. 1998 Oct;28(10):3120-7.

4. Hoover DB, et al. J Pharmacol Exp Ther. 2009 Oct;331(1):197-203.

Maxadilan

生物&药学活性

物理化学性质&存储条件

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Maxadilan

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