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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-TRP Channel-Mavatrep
Mavatrep

Chemical Structure : Mavatrep

CAS No.: 956274-94-5

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Mavatrep (JNJ-39439335, JNJ 39439335)

货号: PC-45093Not For Human Use, Lab Use Only.

Mavatrep (JNJ-39439335) is a potent, selective, high-affinity TRPV1 antagonist with IC50 of 4.6 nM (inhibition of capsaicin-induced Ca(2+) influx).

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5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3780 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Mavatrep (JNJ-39439335) is a potent, selective, high-affinity TRPV1 antagonist with IC50 of 4.6 nM (inhibition of capsaicin-induced Ca(2+) influx).
Mavatrep (JNJ-39439335) exhibits potent in vitro functional activity and robust oral efficacy in multiple models of inflammatory pain.

物理化学性质&存储条件

分子量 422.4423
分子式 C25H21F3N2O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 28 mg/mL
Chemical Name/SMILES

Benzenemethanol, α,α-dimethyl-2-[2-[(1E)-2-[4-(trifluoromethyl)phenyl]ethenyl]-1H-benzimidazol-6-yl]-

参考文献

1. Parsons WH, et al. J Med Chem. 2015 May 14;58(9):3859-74.

2. Mayorga AJ, et al. Scand J Pain. 2017 Aug 24;17:134-143.

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