Mavacamten (SAR439152, MYK-461)

Chemical Structure : Mavacamten

CAS No.: 1642288-47-8

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货号: PC-60047Not For Human Use, Lab Use Only.

Mavacamten (SAR439152, MYK-461) is a small molecule that reduces contractility by decreasing the ATPase activity of the cardiac myosin heavy chain, with IC50 of 490 and 711 nM for bovine cardiac and human cardiac myosin, respectively.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1380	In stock
50 mg	￥2180	In stock
100 mg	￥3580	In stock
250 mg		Get quote

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生物&药学活性

Mavacamten (SAR439152, MYK-461) is a small molecule that reduces contractility by decreasing the ATPase activity of the cardiac myosin heavy chain, with IC50 of 490 and 711 nM for bovine cardiac and human cardiac myosin, respectively.
Mavacamten (SAR439152, MYK-461) inhibits α and β isoforms of cardiac myosin with similar activity (IC50=0.3 uM).
Mavacamten (SAR439152, MYK-461) suppresses the development of ventricular hypertrophy, cardiomyocyte disarray, and myocardial fibrosis and attenuates hypertrophic and profibrotic gene expression in mice harboring heterozygous human mutations in the myosin heavy chain.

物理化学性质&存储条件

分子量	273.336
分子式	C15H19N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-isopropyl-6-((1-phenylethyl)amino)pyrimidine-2,4(1H,3H)-dione

参考文献

1. Green EM, et al. Science. 2016 Feb 5;351(6273):617-21.

2. Stern JA, et al. PLoS One. 2016 Dec 14;11(12):e0168407.

3. Kawas RF, et al. J Biol Chem. 2017 Oct 6;292(40):16571-16577.