Masitinib (AB-1010) mesylate | c-Kit/PDGFR inhibitor | Probechem Biochemicals

Chemical Structure : Masitinib mesylate

CAS No.: 1048007-93-7

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Masitinib mesylate (AB1010 mesylate, AB-1010 mesylate)

货号: PC-42455Not For Human Use, Lab Use Only.

Masitinib (AB-1010) mesylate is a potent tyrosine kinase inhibitor targeting c-Kit and PDGFR with IC50 of 0.15 and 0.05 uM in cell based assays.

规格	价格	库存
50 mg	￥880	In stock
100 mg	￥1280	In stock
250 mg	￥2280	In stock
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生物&药学活性

Masitinib (AB-1010) mesylate is a potent tyrosine kinase inhibitor targeting c-Kit and PDGFR with IC50 of 0.15 and 0.05 uM in cell based assays.
Masitinib (AB-1010) also inhibits Lyn, and to a lesser extent, FGFR3, and inhibits KIT gain-of-function mutants V559D (IC50=3.0 nM) and Δ27 mouse mutant (IC50=5 nM).
Masitinib (AB-1010) dose-dependently inhibits SCF-induced cell proliferation in Ba/F3 cells expressing human wild-type KIT (IC50=150 nM); inhibits tumour growth in vivo.

物理化学性质&存储条件

分子量	594.748
分子式	C29H34N6O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 30 mg/mL
Chemical Name/SMILES	Benzamide, 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]-, methanesulfonate (1:1)

参考文献

1. Dubreuil P, et al. PLoS One. 2009 Sep 30;4(9):e7258.

2. Humbert M, et al. Allergy. 2009 Aug;64(8):1194-201.

3. Tebib J, et al. Arthritis Res Ther. 2009;11(3):R95.

Masitinib mesylate (AB1010 mesylate, AB-1010 mesylate)

生物&药学活性

物理化学性质&存储条件

参考文献

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Masitinib mesylate (AB1010 mesylate, AB-1010 mesylate)

生物&药学活性

物理化学性质&存储条件

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