Masitinib | c-Kit/PDGFR inhibitor | Probechem Biochemicals

Chemical Structure : Masitinib

CAS No.: 790299-79-5

加入收藏

Masitinib (AB1010, AB-1010)

货号: PC-42454Not For Human Use, Lab Use Only.

Masitinib (AB1010) is a potent tyrosine kinase inhibitor targeting c-Kit and PDGFR with IC50 of 0.15 and 0.05 uM in cell based assays.

规格	价格	库存
50 mg	￥880	In stock
100 mg	￥1480	In stock
250 mg	￥2280	In stock
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Masitinib (AB1010) is a potent tyrosine kinase inhibitor targeting c-Kit and PDGFR with IC50 of 0.15 and 0.05 uM in cell based assays.
Masitinib (AB1010) also inhibits Lyn, and to a lesser extent, FGFR3, and inhibits KIT gain-of-function mutants V559D (IC50=3.0 nM) and Δ27 mouse mutant (IC50=5 nM).
Masitinib (AB1010) dose-dependently inhibits SCF-induced cell proliferation in Ba/F3 cells expressing human wild-type KIT (IC50=150 nM); inhibits tumour growth in vivo.

物理化学性质&存储条件

分子量	498.6424
分子式	C28H30N6OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 26 mg/mL
Chemical Name/SMILES	Benzamide, 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]-

参考文献

1. Dubreuil P, et al. PLoS One. 2009 Sep 30;4(9):e7258.

2. Humbert M, et al. Allergy. 2009 Aug;64(8):1194-201.

3. Tebib J, et al. Arthritis Res Ther. 2009;11(3):R95.

Masitinib (AB1010, AB-1010)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Masitinib (AB1010, AB-1010)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.