Chemical Structure : Martinostat
CAS No.: 1629052-58-9
货号: PC-25110Not For Human Use, Lab Use Only.
Martinostat is a potent, selective inhibitor for class I and class-IIb HDACs with IC50 of 0.3/2.0/0.6 nM for HDAC1/2/3 and 4.1 nM for HDAC6 respectively, >100-fold selectivity over other HDAC isoforms.
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---|---|---|---|
5 mg | ¥980 | In stock | |
10 mg | ¥1480 | In stock | |
25 mg | ¥2580 | In stock | |
50 mg | Get quote | ||
100 mg | Get quote |
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Martinostat is a potent, selective inhibitor for class I and class-IIb HDACs with IC50 of 0.3/2.0/0.6 nM for HDAC1/2/3 and 4.1 nM for HDAC6 respectively, >100-fold selectivity over other HDAC isoforms.
[(11)C]Martinostat could be suesfor quantitative imaging of HDACs in vivo in the central nervous system and major peripheral organs.
Martinostat demonstrated enhanced anticancer effects when combined with imatinib, both in vitro and in vivo, significantly reducing tumor growth in resistant CML xenograft models.
分子量 | 354.49 | |
分子式 | C22H30N2O2 | |
外观性状 | Solid | |
储存条件 |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
(E)-3-(4-(((adamantan-1-ylmethyl)(methyl)amino)methyl)phenyl)-N-hydroxyacrylamide |
1. Wey HY, et al. ACS Chem Neurosci. 2015 May 20;6(5):708-15.
2. Strebl MG, et al. ACS Chem Neurosci. 2016 May 18;7(5):528-33.
3. Changning Wang, et al. J Med Chem. 2014 Oct 9;57(19):7999-8009.
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