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首页-小分子抑制剂&激动剂-Epigenetics-HDAC-Martinostat
Martinostat

Chemical Structure : Martinostat

CAS No.: 1629052-58-9

Martinostat

货号: PC-25110Not For Human Use, Lab Use Only.

Martinostat is a potent, selective inhibitor for class I and class-IIb HDACs with IC50 of 0.3/2.0/0.6 nM for HDAC1/2/3 and 4.1 nM for HDAC6 respectively, >100-fold selectivity over other HDAC isoforms.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Martinostat is a potent, selective inhibitor for class I and class-IIb HDACs with IC50 of 0.3/2.0/0.6 nM for HDAC1/2/3 and 4.1 nM for HDAC6 respectively, >100-fold selectivity over other HDAC isoforms.
[(11)C]Martinostat could be suesfor quantitative imaging of HDACs in vivo in the central nervous system and major peripheral organs.
Martinostat demonstrated enhanced anticancer effects when combined with imatinib, both in vitro and in vivo, significantly reducing tumor growth in resistant CML xenograft models.

物理化学性质&存储条件

分子量 354.49
分子式 C22H30N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(E)-3-(4-(((adamantan-1-ylmethyl)(methyl)amino)methyl)phenyl)-N-hydroxyacrylamide

参考文献

1. Wey HY, et al. ACS Chem Neurosci. 2015 May 20;6(5):708-15.

2. Strebl MG, et al. ACS Chem Neurosci. 2016 May 18;7(5):528-33.

3. Changning Wang, et al. J Med Chem. 2014 Oct 9;57(19):7999-8009.

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