Chemical Structure : Margetuximab
CAS No.: 1350624-75-7
货号: PC-Ab1036Not For Human Use, Lab Use Only.
Margetuximab (MGAH22) is a Fc engineered HER2-directed monoclonal antibody, increases activation of innate and adaptive anti-ERBB2 immune responses, relative to trastuzumab. Margetuximab binds to the same epitope as trastuzumab, but its Fc domain has been modified to enhance binding to activating FcγRIIIA (CD16A) and reduce its affinity for inhibitory FcγRIIB (CD32B) receptors..
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥3580 | In stock | |
5 mg | ¥7580 | In stock | |
10 mg | ¥12800 | In stock | |
100 mg | Get quote |
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Margetuximab (MGAH22) is a Fc engineered HER2-directed monoclonal antibody, increases activation of innate and adaptive anti-ERBB2 immune responses, relative to trastuzumab. Margetuximab binds to the same epitope as trastuzumab, but its Fc domain has been modified to enhance binding to activating FcγRIIIA (CD16A) and reduce its affinity for inhibitory FcγRIIB (CD32B) receptors.
分子量 | ||
分子式 | Human IgG1-Kappa | |
外观性状 | Solid | |
储存条件 |
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Solubility |
PBS, pH 7.0 Contains no stabilizers or preservatives |
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Chemical Name/SMILES |
Margetuximab; Margenza; Margetuximab-cmkb; MGAH22; HER2; ERBB2; erb-b2 receptor tyrosine kinase 2; human epidermal growth factor receptor 2; EGFR2 |
1. 1, Rugo HS, et al. JAMA Oncol. 2021 Apr 1;7(4):573-584. 2, Catenacci DVT, et al. Lancet Oncol. 2020 Aug;21(8):1066-1076. 3, Catenacci DV, et al. Future Oncol. 2021 Apr;17(10):1155-1164. 4, Nordstrom JL, et al. Breast Cancer Res. 2011;13(6):R123.
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