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首页-抗体和重组蛋白-Biosimilar Antibody-Margetuximab
Margetuximab

Chemical Structure : Margetuximab

CAS No.: 1350624-75-7

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Margetuximab (Anti-human HER2 mAb, human IgG1-Kappa; MGAH22)

货号: PC-Ab1036Not For Human Use, Lab Use Only.

Margetuximab (MGAH22) is a Fc engineered HER2-directed monoclonal antibody, increases activation of innate and adaptive anti-ERBB2 immune responses, relative to trastuzumab. Margetuximab binds to the same epitope as trastuzumab, but its Fc domain has been modified to enhance binding to activating FcγRIIIA (CD16A) and reduce its affinity for inhibitory FcγRIIB (CD32B) receptors..

规格 价格 库存 数量
1 mg ￥3580 In stock
5 mg ￥7580 In stock
10 mg ￥12800 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Margetuximab (MGAH22) is a Fc engineered HER2-directed monoclonal antibody, increases activation of innate and adaptive anti-ERBB2 immune responses, relative to trastuzumab. Margetuximab binds to the same epitope as trastuzumab, but its Fc domain has been modified to enhance binding to activating FcγRIIIA (CD16A) and reduce its affinity for inhibitory FcγRIIB (CD32B) receptors.

物理化学性质&存储条件

分子量
分子式 Human IgG1-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Margetuximab; Margenza; Margetuximab-cmkb; MGAH22; HER2; ERBB2; erb-b2 receptor tyrosine kinase 2; human epidermal growth factor receptor 2; EGFR2

参考文献

1. 1, Rugo HS, et al. JAMA Oncol. 2021 Apr 1;7(4):573-584. 2, Catenacci DVT, et al. Lancet Oncol. 2020 Aug;21(8):1066-1076. 3, Catenacci DV, et al. Future Oncol. 2021 Apr;17(10):1155-1164. 4, Nordstrom JL, et al. Breast Cancer Res. 2011;13(6):R123.

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