Marbotinib | FLT3 inhibitor | Probechem Biochemicals

Chemical Structure : Marbotinib

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Marbotinib (FLT3i-3, Methanone 16)

货号: PC-72543Not For Human Use, Lab Use Only.

Marbotinib (FLT3i-3, Methanone 16) is a highly potent, specific, next-generation FLT3 inhibitor.

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生物&药学活性

Marbotinib is a highly potent, specific, next-generation FLT3 inhibitor.
Marbotinib induced 91% cell death in MV4-11 cells (IC50=3 nM) at 5 nM in comparison with quizartinib (IC50 3 nM) and FLT3i-469 (IC50 4 nM).
Marbotinib is a low-nanomolar and highly specific inhibitor of mutant FLT3 and of the growth of AML cells with FLT3-ITD and FLT3-TKD mutations.
Marbotinib suppresses the phosphorylation of FLT3-ITD and the growth of permanent and primary AML cells with FLT3-ITD, Marbotinib shows high selectivity for FLT3 and alters signaling, reminiscent of genetic elimination of FLT3-ITD.
The water-soluble marbotinib-carbamate significantly prolongs survival of mice with FLT3-driven leukemia.

物理化学性质&存储条件

分子量	458.474
分子式	C25H22N4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(5-(tert-butyl)isoxazol-3-yl)-3-(2-(5-hydroxy-1H-indole-2-carbonyl)benzofuran-5-yl)urea

参考文献

1. Mandy Beyer, et al. Cell Chem Biol. 2021 Nov 9;S2451-9456(21)00475-X.

Marbotinib (FLT3i-3, Methanone 16)

生物&药学活性

物理化学性质&存储条件

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Marbotinib (FLT3i-3, Methanone 16)

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物理化学性质&存储条件

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