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首页-小分子抑制剂&激动剂-GPCR-Chemokine Receptor (CCR and CXCR)-Maraviroc
Maraviroc

Chemical Structure : Maraviroc

CAS No.: 376348-65-1

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Maraviroc (UK427857, UK-427857)

货号: PC-21897Not For Human Use, Lab Use Only.

Maraviroc (UK-427857) is a potent, selective and orally bioavailable CCR5 inhibitor with IC50 of 3.3 nM, 7.2 nM and 5.2 nM for MIP-1α, MIP-1β and RANTES binding to cell membrane preparations of CCR5-expressing HEK-293, shows broad-spectrum activity against HIV-1.

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10 mg ￥880 In stock
25 mg ￥1480 In stock
50 mg ￥2380 In stock
100 mg ￥3980 In stock
200 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Maraviroc (UK-427857) is a potent, selective and orally bioavailable CCR5 inhibitor with IC50 of 3.3 nM, 7.2 nM and 5.2 nM for MIP-1α, MIP-1β and RANTES binding to cell membrane preparations of CCR5-expressing HEK-293, shows broad-spectrum activity against HIV-1.
Maraviroc (UK-427857) shows potent antiviral activity against the 43 primary CCR5-tropic HIV-1 isolates with a geometric mean IC90 of 2.0 nM.
Maraviroc (UK-427857) does not affect CCR5 cell surface levels or associated intracellular signaling.
Maraviroc (UK-427857) has no detectable in vitro cytotoxicity and is highly selective for CCR5, as confirmed against a wide range of receptors and enzymes, including the hERG ion channel.

物理化学性质&存储条件

分子量 513.68
分子式 C29H41F2N5O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4,4-Difluoro-N-((S)-3-((1R,3R,5S)-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl)-1-phenylpropyl)cyclohexane-1-carboxamide

参考文献

1. Dorr P, et al. Antimicrob Agents Chemother. 2005 Nov;49(11):4721-32.

2. Wood A, et al. Prog Med Chem. 2005;43:239-71.

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