Mapracorat | GR agonist | Probechem Biochemicals

Chemical Structure : Mapracorat

CAS No.: 887375-26-0

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Mapracorat (ZK 245186, BOL 303242X, BAY865319)

货号: PC-61603Not For Human Use, Lab Use Only.

Mapracorat (ZK 245186) is a potent, selective and non-steroid glucocorticoid receptor (GR) agonist with binding Ki of 1.9 nM.

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生物&药学活性

Mapracorat (ZK 245186) is a potent, selective and non-steroid glucocorticoid receptor (GR) agonist with binding Ki of 1.9 nM.
Mapracorat (ZK 245186) does not show significant activity for ERα, PR, AR or MR.
Mapracorat (ZK 245186) shows anti-inflammatory efficacy after topical application similar to the classical glucocorticoids, with a better safety profile.

物理化学性质&存储条件

分子量	462.489
分子式	C25H26F4N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R)-1,1,1-trifluoro-4-(5-fluoro-2,3-dihydro-1-benzofuran-7-yl)-4-methyl-2-[[(2-methylquinolin-5-yl)amino]methyl]pentan-2-ol

参考文献

1. Schäcke H, et al. Br J Pharmacol. 2009 Oct;158(4):1088-103.

2. Zhang JZ, et al. Mol Vis. 2009 Dec 8;15:2606-16.

3. Shafiee A, et al. Invest Ophthalmol Vis Sci. 2011 Mar 14;52(3):1422-30.

Mapracorat (ZK 245186, BOL 303242X, BAY865319)

生物&药学活性

物理化学性质&存储条件

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Mapracorat (ZK 245186, BOL 303242X, BAY865319)

生物&药学活性

物理化学性质&存储条件

参考文献

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