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首页-抗体和重组蛋白-Biosimilar Antibody-Magrolimab
Magrolimab

Chemical Structure : Magrolimab

CAS No.: 2169232-81-7

Magrolimab (Anti-human CD47 mAb, human IgG4-Kappa)

货号: PC-Ab1002Not For Human Use, Lab Use Only.

A monoclonal anti-human CD47 antibody by grafting its complementarity determining regions (CDRs) onto a human IgG4 format.

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1 mg ¥3580 In stock
5 mg ¥7580 In stock
10 mg ¥12800 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

A monoclonal anti-human CD47 antibody by grafting its complementarity determining regions (CDRs) onto a human IgG4 format; bound to monomeric human CD47 with an 8 nM affinity; induced potent macrophage-mediated phagocytosis of primary human AML cells in vitro and completely eradicated human AML in vivo, leading to long-term disease-free survival of patient-derived xenografts.

物理化学性质&存储条件

分子量
分子式 Human IgG4-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives

Chemical Name/SMILES

Magrolimab; Hu5F9-G4; 5F9; 2169232-81-7; anti Leukocyte surface antigen CD47; Cluster of differentiation 47; CD47 Antigen (Rh-Related Antigen, Integrin-Associated Signal Transducer)

参考文献

1. 1, Sikic BI, et al. J Clin Oncol. 2019 Apr 20;37(12):946-953. 2, Advani R, et al. N Engl J Med. 2018 Nov 1;379(18):1711-1721. 3, Gholamin S, et al. Sci Transl Med. 2017 Mar 15;9(381):eaaf2968. 4, Liu J, et al. PLoS One. 2015 Sep 21;10(9):e0137345. 

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