Chemical Structure : Magrolimab
CAS No.: 2169232-81-7
货号: PC-Ab1002Not For Human Use, Lab Use Only.
A monoclonal anti-human CD47 antibody by grafting its complementarity determining regions (CDRs) onto a human IgG4 format.
规格 | 价格 | 库存 | 数量 |
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1 mg | ¥3580 | In stock | |
5 mg | ¥7580 | In stock | |
10 mg | ¥12800 | In stock | |
100 mg | Get quote |
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A monoclonal anti-human CD47 antibody by grafting its complementarity determining regions (CDRs) onto a human IgG4 format; bound to monomeric human CD47 with an 8 nM affinity; induced potent macrophage-mediated phagocytosis of primary human AML cells in vitro and completely eradicated human AML in vivo, leading to long-term disease-free survival of patient-derived xenografts.
分子量 | ||
分子式 | Human IgG4-Kappa | |
外观性状 | Solid | |
储存条件 |
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Solubility |
PBS, pH 7.0 Contains no stabilizers or preservatives |
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Chemical Name/SMILES |
Magrolimab; Hu5F9-G4; 5F9; 2169232-81-7; anti Leukocyte surface antigen CD47; Cluster of differentiation 47; CD47 Antigen (Rh-Related Antigen, Integrin-Associated Signal Transducer) |
1. 1, Sikic BI, et al. J Clin Oncol. 2019 Apr 20;37(12):946-953. 2, Advani R, et al. N Engl J Med. 2018 Nov 1;379(18):1711-1721. 3, Gholamin S, et al. Sci Transl Med. 2017 Mar 15;9(381):eaaf2968. 4, Liu J, et al. PLoS One. 2015 Sep 21;10(9):e0137345.
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