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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-ERK-Magnolin
Magnolin

Chemical Structure : Magnolin

CAS No.: 31008-18-1

Magnolin

货号: PC-28581Not For Human Use, Lab Use Only.

Magnolin is a major component of Magnolia liliiflora, inhibits the Ras/ERKs/RSK2 signaling axis by targeting the active pocket of ERK1 and ERK2 with IC50 of 87 nM and 16.5 nM, respectively, has excellent antioxidant, anti-inflammatory and anti-cancer properties, also is a selective HCAR1 inhibitor with IC50 of 7.1 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Magnolin is a major component of Magnolia liliiflora, inhibits the Ras/ERKs/RSK2 signaling axis by targeting the active pocket of ERK1 and ERK2 with IC50 of 87 nM and 16.5 nM, respectively, has excellent antioxidant, anti-inflammatory and anti-cancer properties, also is a selective HCAR1 inhibitor with IC50 of 7.1 uM.

物理化学性质&存储条件

分子量 416.47
分子式 C23H28O7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(1S,3aR,4S,6aR)-1-(3,4-Dimethoxyphenyl)-4-(3,4,5-trimethoxyphenyl)tetrahydro-1H,3H-furo[3,4-c]furan

参考文献

1. Lee CJ, et al. BMC Cancer. 2015 Aug 8;15:576.

2. Zheng L, et al. Chem Commun (Camb). 2026 Oct 14. doi: 10.1039/d6cc02998a.

3. Zhang M, et al. Int Immunopharmacol. 2024 Jun 15;134:112181.

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