Macrocyclic peptide D4-2

Chemical Structure : Macrocyclic peptide D4-2

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货号: PC-72498Not For Human Use, Lab Use Only.

Macrocyclic peptide D4-2 is a macrocyclic peptide consisting of 15 amino acids that binds to the ectodomain of mouse SIRPα (Kd=10 nM, IgV-B6 SIRPα) and efficiently blocks CD47-SIRPα interaction in an allosteric manner (IC50=0.18 uM).

规格	价格	库存	数量
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50 mg		Get quote
100 mg		Get quote

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生物&药学活性

Macrocyclic peptide D4-2 is a macrocyclic peptide consisting of 15 amino acids that binds to the ectodomain of mouse SIRPα (Kd=10 nM, IgV-B6 SIRPα) and efficiently blocks CD47-SIRPα interaction in an allosteric manner (IC50=0.18 uM).
D4-2 showed a high binding affinity for the Ig-V-like domain of NOD mouse SIRPα (IgV-NOD SIRPα; KD = 8.22 nM).
D4-2 markedly promoted the phagocytosis of antibody-opsonized tumor cells by macrophages in vitro as well as enhanced the inhibitory effect of anti-CD20 or anti-gp75 antibodies on tumor formation or metastasis in vivo.

物理化学性质&存储条件

分子量	1843.05
分子式	C85H115N23O22S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,6S,9R,15R,18S,21S,24S,27S,30S,33S,36S,39S,42S,47aS)-42-((1H-imidazol-5-yl)methyl)-6-((1H-indol-3-yl)methyl)-39-amino-N-(2-amino-2-oxoethyl)-39-((S)-sec-butyl)-18-(3-guanidinopropyl)-15,21,33-tris(4-hydroxybenzyl)-3,24,36-tris(hydroxymethyl)-30-isopropyl-27-methyl-1,4,7,13,16,19,22,25,28,31,34,37,40,43-tetradecaoxohexatetracontahydropyrrolo[1,2-h1][1]thia[4,7,10,13,16,19,22,25,28,31,34,37,40,43]tetradecaazacyclopentatetracontine-9-carboxamide

参考文献

1. Daisuke Hazama, et al. Cell Chem Biol. 2020 Sep 17;27(9):1181-1191.e7.