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Macozinone

Chemical Structure : Macozinone

CAS No.: 1377239-83-2

Macozinone (PBTZ169, PBTZ-169)

货号: PC-61388Not For Human Use, Lab Use Only.

Macozinone (PBTZ-169, PBTZ169) is a potent, second-generation antituberculosis agent that inhibits DprE1 and displays nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro.

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10 mg ¥1280 In stock
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50 mg ¥3780 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Macozinone (PBTZ-169, PBTZ169) is a potent, second-generation antituberculosis agent that inhibits DprE1 and displays nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro.
PBTZ169 is less cytotoxic than BTZ043 and shows significantly better efficacy at lower concentrations in the murine model of chronic TB, inhibits DprE1 more efficiently than BTZ043.

物理化学性质&存储条件

分子量 456.484
分子式 C20H23F3N4O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2-[4-(cyclohexylmethyl)piperazin-1-yl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one

参考文献

1. Makarov V, et al. EMBO Mol Med. 2014 Mar;6(3):372-83.

2. Makarov V, et al. Antimicrob Agents Chemother. 2015 Aug;59(8):4446-52.

3. González-Martínez NA, et al. PLoS Negl Trop Dis. 2015 Oct 16;9(10):e0004022.

4. Lechartier B, et al. Antimicrob Agents Chemother. 2015 Aug;59(8):4457-63.

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