Macitentan | Endothelin receptor antagonist | Probechem Biochemicals

Chemical Structure : Macitentan

CAS No.: 441798-33-0

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Macitentan (ACT-064992, ACT064992)

货号: PC-25044Not For Human Use, Lab Use Only.

Macitentan (ACT-064992) is a potent, selective and orally active dual ETA/ETB endothelin receptor antagonist with binding IC50 of 0.5/391 nM for ETA/ETB receptors respectively.

规格	价格	库存
10 mg	￥380	In stock
25 mg	￥580	In stock
50 mg	￥880	In stock
100 mg	￥1280	In stock
500 mg		Get quote

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生物&药学活性

Macitentan (ACT-064992) is a potent, selective and orally active dual ETA/ETB endothelin receptor antagonist with binding IC50 of 0.5/391 nM for ETA/ETB receptors respectively.

物理化学性质&存储条件

分子量	588.28
分子式	C19H20Br2N6O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-(4-Bromophenyl)-6-(2-((5-bromo-2-pyrimidinyl)oxy)ethoxy)-4-pyrimidinyl)-N'-propylsulfamide

参考文献

1. Iglarz M, et al. J Pharmacol Exp Ther. 2008 Dec;327(3):736-45.

2. Bolli MH, et al. J Med Chem. 2012 Sep 13;55(17):7849-61.

Macitentan (ACT-064992, ACT064992)

生物&药学活性

物理化学性质&存储条件

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Macitentan (ACT-064992, ACT064992)

生物&药学活性

物理化学性质&存储条件

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