MZH29 | FLT3 inhibitor | Probechem Biochemicals

Chemical Structure : MZH29

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MZH29 (MZH 29)

货号: PC-35238Not For Human Use, Lab Use Only.

MZH29 is a novel potent, selective, orally active type II FLT3 inhibitor with IC50 of 9 nM and 7 nM against FLT3-WT and FLT3-ITD, respectively.

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生物&药学活性

MZH29 is a novel potent, selective, orally active type II FLT3 inhibitor with IC50 of 9 nM and 7 nM against FLT3-WT and FLT3-ITD, respectively.
MZH29 shows little to no inhibition for c-Kit in a panel of 50kinases。
MZH29 efficiently induces apoptosis and inhibits FLT3 phosphorylation in vitro, inhibited the phosphorylation of FLT3, Stat5, ERK, and c-MYC in MV4-11, MOLM-11, and NOMO-1 cells。
MZH29 inhibits FLT3-ITD/F691L and FLT3-D835V autophosphorylation and downstream signaling more potently than AC220, overcomes drug resistance in FLT3 mutant cells。
MZH29 caused complete tumor regression and extended survival in a mouse model of AML with less toxicity (10 mg/kg).

物理化学性质&存储条件

分子量	560.626
分子式	C31H33FN4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-fluoro-4-((6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yl)oxy)phenyl)-3-(m-tolyl)urea

参考文献

1. Xu B, et al. Leukemia. 2017 Apr;31(4):913-921.

MZH29 (MZH 29)

生物&药学活性

物理化学性质&存储条件

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MZH29 (MZH 29)

生物&药学活性

物理化学性质&存储条件

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