MZ-101 | Glycogen synthase 1 inhibitor | Probechem Biochemicals

Chemical Structure : MZ-101

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MZ-101 (MZ101)

货号: PC-21680Not For Human Use, Lab Use Only.

MZ-101 is a potent, selective inhibitor of glycogen synthase 1 (GYS1) with IC50 of 41 nM (human GYS1), with no inhibition against GYS2.

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生物&药学活性

MZ-101 is a potent, selective inhibitor of glycogen synthase 1 (GYS1) with IC50 of 41 nM (human GYS1), with no inhibition against GYS2.
MZ-101 shows similar potency and selectivity of MZ-101 for the mouse isoform of GYS1.
MZ-101 potently and selectively inhibits GYS1 by a noncompetitive mechanism.
MZ-101 reduces glycogen abundance in a dose-dependent manner in fibroblasts from healthy controls and patients with Pompe disease with a mean EC50 of 500 nM.
MZ-101 inhibits glycogen synthesis across species and cell types expressing GYS1, independent of defects in glycogen catabolism.
MZ-101 inhibits GYS1 but not GYS2 de novo glycogen synthesis in WT and Pompe mice.

物理化学性质&存储条件

分子量	449.53
分子式	C25H28FN5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,4R)-1-(2-(1H-1,2,3-triazol-5-yl)acetyl)-4-fluoro-N-((S)-(4-isopropylphenyl)(phenyl)methyl)pyrrolidine-2-carboxamide

参考文献

1. Ullman JC, et al. Sci Transl Med. 2024 Jan 17;16(730):eadf1691.

MZ-101 (MZ101)

生物&药学活性

物理化学性质&存储条件

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MZ-101 (MZ101)

生物&药学活性

物理化学性质&存储条件

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