MYC inhibitor EN4 | MYC covalent inhibitor | Probechem Biochemicals

Chemical Structure : MYC inhibitor EN4

CAS No.: 1197824-15-9

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MYC inhibitor EN4 (EN4)

货号: PC-73141Not For Human Use, Lab Use Only.

MYC inhibitor EN4 is a covalent ligand and inhibitor of MYC, targets cysteine 171 of MYC and inhibits MYC transcriptional activity (EC50=2.8 uM).

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10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2480	In stock
100 mg		Get quote

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生物&药学活性

MYC inhibitor EN4 is a covalent ligand and inhibitor of MYC, targets cysteine 171 of MYC and inhibits MYC transcriptional activity (EC50=2.8 uM).
EN4 inhibited MYC/MAX binding to the E-box response element DNA consensus sequence in a dose-responsive manner with EC50 of 6.7 uM.
EN4 directly and covalently modifies pure full-length c-MYC protein at C171 to inhibit MYC/MAX DNA binding in vitro.
EN4 engages MYC in cells, reduced MYC and MAX thermal stability in 231MFP breast cancer cells.
EN4 downregulates multiple MYC transcriptional targets, and impairs tumorigenesis.

物理化学性质&存储条件

分子量	416.477
分子式	C25H24N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(Acrylamidomethyl)-N-(2-(4-ethoxyphenoxy)phenyl)benzamide

参考文献

1. Lydia Boike, et al. Cell Chem Biol. 2021 Jan 21;28(1):4-13.e17.

MYC inhibitor EN4 (EN4)

生物&药学活性

物理化学性质&存储条件

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MYC inhibitor EN4 (EN4)

生物&药学活性

物理化学性质&存储条件

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