MYC inhibitor DC-34 |CAS 1966107-70-9 Probechem Biochemicals

Chemical Structure : MYC inhibitor DC-34

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MYC inhibitor DC-34 (DC-34)

货号: PC-35731Not For Human Use, Lab Use Only.

MYC inhibitor DC-34 is a potent small molecule that selectively inhibits MYC at the transcriptional level only when a G-quadruplex (G4) is present in the promoter, binds to MYC G4 with Kd of 9.4 uM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

MYC inhibitor DC-34 is a potent small molecule that selectively inhibits MYC at the transcriptional level only when a G-quadruplex (G4) is present in the promoter, binds to MYC G4 with Kd of 9.4 uM.
MYC inhibitor DC-34 does not transcriptionally downregulate several other G4-dependent genes to the same extent.
MYC inhibitor DC-34 binds independently to the MYC G4 3'and 5' ends, demonstrates cytotoxicity in L363 MM cells with IC50 of 3.5 uM.

物理化学性质&存储条件

分子量	446.47
分子式	C24H25F3N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(azepan-1-ylmethyl)-5-hydroxy-2-methyl-N-(4-(trifluoromethyl)phenyl)benzofuran-3-carboxamide

参考文献

1. Calabrese DR, et al. Nat Commun. 2018 Oct 12;9(1):4229.

2. Felsenstein KM, et al. ACS Chem Biol. 2016 Jan 15;11(1):139-48.

MYC inhibitor DC-34 (DC-34)

生物&药学活性

物理化学性质&存储条件

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MYC inhibitor DC-34 (DC-34)

生物&药学活性

物理化学性质&存储条件

参考文献

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