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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-c-Myc-MYCi361
MYCi361

Chemical Structure : MYCi361

CAS No.: 2289690-31-7

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MYCi361 (NUCC-0196361, MYC inhibitor 361)

货号: PC-73126Not For Human Use, Lab Use Only.

MYCi361 (NUCC-0196361) is a small molecule MYC inhibitor, binds to MYC protein with KD of 3.2 uM, disrupts MYC/MAX complex formation.

规格 价格 库存 数量
5 mg ￥1980 In stock
10 mg ￥2980 In stock
25 mg ￥4780 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MYCi361 (NUCC-0196361) is a small molecule MYC inhibitor, binds to MYC protein with KD of 3.2 uM, disrupts MYC/MAX complex formation.
MYCi361 impaired MYC/MAX heterodimer but not the closely related MAX/MAX homodimer binding to E-box DNA.
MYCi361 disrupts the MYC/MAX interaction in PC3 cells at concentration 6 μM for 1 hr.
MYCi361 decreases MYC protein stability by modulating MYC-threonine 58 phosphorylation.
MYCi361 inhibits cell proliferatin ona panel of MYC-dependent and -independent cell lines (LNCaP cell IC50 =1.4 uM, MV411, IC50=2.6 uM).
MYCi361 shows favorable pharmacokinetics and inhibits MYC-driven tumor growth in vivo.
MYCi361 modulates the tumor immune microenvironment and enhances anti-PD1 immunotherapy.

物理化学性质&存储条件

分子量 594.86
分子式 C26H16ClF9N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-((4-chlorobenzyl)oxy)-3-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-3',5'-bis(trifluoromethyl)-[1,1'-biphenyl]-2-ol

参考文献

1. Han H, et al. Cancer Cell. 2019 Nov 11;36(5):483-497.e15.

2. Ding T, et al. Front Cell Dev Biol. 2021 Feb 26;9:644397.

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