MYCMI-7 | MYC-MAX inhibitor | Probechem Biochemicals

Chemical Structure : MYCMI-7

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MYCMI-7 (MYCMI7)

货号: PC-73228Not For Human Use, Lab Use Only.

MYCMI-7 is a small molecule MYC-binding compound (Kd=4 uM) that inhibits MYC-MAX interaction.

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250 mg		Get quote

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生物&药学活性

MYCMI-7 is a small molecule MYC-binding compound (Kd=4 uM) that inhibits MYC-MAX interaction.
MYCMI-7 efficiently and selectively inhibits MYC:MAX and MYCN:MAX interactions in cells, binds directly to recombinant MYC, and reduces MYC-driven transcription.
MYCMI-7 induces degradation of MYC and MYCN proteins.
MYCMI-7 potently induces growth arrest/apoptosis in tumor cells in a MYC/MYCN-dependent manner and downregulates the MYC pathway on a global level.
MYCMI-7 downregulates MYC/MYCN, inhibits tumor growth, and prolongs survival through apoptosis in mouse tumor models of MYC-driven AML, breast cancer, and MYCN-amplified neuroblastoma.

物理化学性质&存储条件

分子量	426.402
分子式	C23H28BrN3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-(diethylamino)ethyl)-5,11-dimethyl-6H-pyrido[4,3-b]carbazol-2-ium bromide

参考文献

1. Alina Castell, et al. Cancer Research Communications (2022) 2 (3): 182–201.

MYCMI-7 (MYCMI7)

生物&药学活性

物理化学性质&存储条件

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MYCMI-7 (MYCMI7)

生物&药学活性

物理化学性质&存储条件

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