MYCMI-6 |CAS:681282-09-7 Probechem Biochemicals

Chemical Structure : MYCMI-6

CAS No.: 681282-09-7

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MYCMI-6 (NSC354961;MYCMI6)

货号: PC-35303Not For Human Use, Lab Use Only.

MYCMI-6 (NSC354961) is a selective, high affinity inhibitor of MYC-MAX interaction, blocks MYC-driven transcription and binds selectively to the MYC bHLHZip domain with Kd of 1.6 uM in SPR assay.

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5 mg	￥2880	In stock
10 mg	￥4780	In stock
25 mg	￥7580	In stock
100 mg		Get quote

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生物&药学活性

MYCMI-6 (NSC354961) is a selective, high affinity inhibitor of MYC-MAX interaction, blocks MYC-driven transcription and binds selectively to the MYC bHLHZip domain with Kd of 1.6 uM in SPR assay.
MYCMI-6 specifcally targets MYC:MAX interaction without interfering with other MYC activities.
MYCMI-6 selectively suppresses MYC-driven tumor cell growth with high efficacy, efficiently inhibits anchorage-independent growth of MYCN-amplifed neuroblastoma cells with GI50 values of <0.4, 5 and 0.75 μM, respectively.
MYCMI-6 reduces proliferation and induces massive apoptosis in tumor tissue from a MYC-driven xenograft tumor model without severe side effects

物理化学性质&存储条件

分子量	373.42
分子式	C20H19N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-((9-amino-7-ethoxyacridin-3-yl)diazenyl)pyridine-2,6-diamine

参考文献

1. Castell A, et al. Sci Rep. 2018 Jul 3;8(1):10064.

MYCMI-6 (NSC354961;MYCMI6)

生物&药学活性

物理化学性质&存储条件

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MYCMI-6 (NSC354961;MYCMI6)

生物&药学活性

物理化学性质&存储条件

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