MY33-3 | PTPRZ1 inhibitor | Probechem Biochemicals

Chemical Structure : MY33-3

CAS No.: 2204280-41-9

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MY33-3 (PTPRZ1 inhibitor MY33-3)

货号: PC-35024Not For Human Use, Lab Use Only.

MY33-3 is a small-molecule inhibitor of RPTPβ/ζ (PTPRZ1) with IC50 of 0.1 uM, significantly increases the phosphorylation of key tyrosine residues of RPTPβ/ζ substrates involved in neuronal survival and differentiation.

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10 mg	￥3980	In stock
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生物&药学活性

MY33-3 is a small-molecule inhibitor of RPTPβ/ζ (PTPRZ1) with IC50 of 0.1 uM, significantly increases the phosphorylation of key tyrosine residues of RPTPβ/ζ substrates involved in neuronal survival and differentiation.
MY33-3 blocks ethanol conditioned place preference, shows limited effects on ethanol-induced ataxia, and potentiates the sedative effects of ethanol in mice.
MY33-3 increases levels of phosphorylated ALK and TrkA in neuroblastoma cells, modulates signaling pathways activated by alcohol.

物理化学性质&存储条件

分子量	397.397
分子式	C16H13F6NS2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	bis(4-((trifluoromethyl)thio)benzyl)amine

参考文献

1. Fernández-Calle R, et al. Neuropharmacology. 2018 May 9;137:86-95.

MY33-3 (PTPRZ1 inhibitor MY33-3)

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MY33-3 (PTPRZ1 inhibitor MY33-3)

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物理化学性质&存储条件

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