MY-9B | SARM1 inhibitor | Probechem Biochemicals

Chemical Structure : MY-9B

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MY-9B (SARM1 inhibitor)

货号: PC-49271Not For Human Use, Lab Use Only.

MY-9B is a selective, allosteric and covalent inhibitor of sterile alpha toll/interleukin receptor motif containing-1 (SARM1) with IC50 of 1.2 uM, site-specifically and stereoselectively modify cysteine-311 (C311) in the noncatalytic, autoregulatory armadillo repeat (ARM) domain of SARM1.

规格	价格	库存	数量
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100 mg		Get quote
250 mg		Get quote

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生物&药学活性

MY-9B is a selective, allosteric and covalent inhibitor of sterile alpha toll/interleukin receptor motif containing-1 (SARM1) with IC50 of 1.2 uM, site-specifically and stereoselectively modify cysteine-311 (C311) in the noncatalytic, autoregulatory armadillo repeat (ARM) domain of SARM1.
MY-9B inhibits the NADase activity of WT-SARM1, but not C311A or C311S SARM1 mutants, show a high degree of proteome-wide selectivity for SARM1 C311.
MY-9B (10-20 uM) stereoselectively blocks vincristine- and vacor-induced neurite degeneration in primary rodent dorsal root ganglion neurons.

物理化学性质&存储条件

分子量	403.438
分子式	C23H21N3O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1R,3R)-2-acryloyl-1-(benzo[d][1,3]dioxol-5-yl)-N-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxamide

参考文献

1. Hannah C Feldman, et al. Proc Natl Acad Sci U S A. 2022 Aug 30;119(35):e2208457119.