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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Phosphodiesterase (PDE)-MY-5445
MY-5445

Chemical Structure : MY-5445

CAS No.: 78351-75-4

MY-5445 (MY5445)

货号: PC-61344Not For Human Use, Lab Use Only.

MY-5445 is a specific PDE5 inhibitor that inhibits human platelet aggregation induced by 3 uM ADP, 3 mg/ml of collagen and 100 ug/ml of arachidonic acid with IC50 of 0.07, 0.02 and 0.17 uM, respectively.

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10 mg ¥1280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MY-5445 is a specific PDE5 inhibitor that inhibits human platelet aggregation induced by 3 uM ADP, 3 mg/ml of collagen and 100 ug/ml of arachidonic acid with IC50 of 0.07, 0.02 and 0.17 uM, respectively.
MY-5445 shows no effect on either adenylate cyclase or guanylate cyclase activity.
MY-5445 inhibits human platelet aggregation by increasing cyclic GMP content.
MY-5445 is a useful probe for elucidating the role of cyclic GMP in platelet aggregation.

物理化学性质&存储条件

分子量 331.8
分子式 C20H14ClN3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(3-Chlorophenyl)-4-phenyl-1-phthalazinamine

参考文献

1. Yamamoto T, et al. J Biol Chem. 1983 Dec 10;258(23):14173-7.

2. Hagiwara M, et al. J Pharmacol Exp Ther. 1984 Feb;228(2):467-71.

3. Souness JE, et al. Br J Pharmacol. 1989 Nov;98(3):725-34.

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