Chemical Structure : MY-5445
CAS No.: 78351-75-4
货号: PC-61344Not For Human Use, Lab Use Only.
MY-5445 is a specific PDE5 inhibitor that inhibits human platelet aggregation induced by 3 uM ADP, 3 mg/ml of collagen and 100 ug/ml of arachidonic acid with IC50 of 0.07, 0.02 and 0.17 uM, respectively.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5 mg | ¥880 | In stock | |
10 mg | ¥1280 | In stock | |
25 mg | ¥2180 | In stock | |
50 mg | Get quote | ||
100 mg | Get quote |
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MY-5445 is a specific PDE5 inhibitor that inhibits human platelet aggregation induced by 3 uM ADP, 3 mg/ml of collagen and 100 ug/ml of arachidonic acid with IC50 of 0.07, 0.02 and 0.17 uM, respectively.
MY-5445 shows no effect on either adenylate cyclase or guanylate cyclase activity.
MY-5445 inhibits human platelet aggregation by increasing cyclic GMP content.
MY-5445 is a useful probe for elucidating the role of cyclic GMP in platelet aggregation.
分子量 | 331.8 | |
分子式 | C20H14ClN3 | |
外观性状 | Solid | |
储存条件 |
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Solubility |
10 mM in DMSO |
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Chemical Name/SMILES |
N-(3-Chlorophenyl)-4-phenyl-1-phthalazinamine |
1. Yamamoto T, et al. J Biol Chem. 1983 Dec 10;258(23):14173-7.
2. Hagiwara M, et al. J Pharmacol Exp Ther. 1984 Feb;228(2):467-71.
3. Souness JE, et al. Br J Pharmacol. 1989 Nov;98(3):725-34.
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