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首页-小分子抑制剂&激动剂-Apoptosis-IAP-MX106
MX106

Chemical Structure : MX106

CAS No.: 2170836-81-2

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MX106 (MX 106)

货号: PC-35080Not For Human Use, Lab Use Only.

MX106 is a novel potent survivin inhibitor, effectively suppresses MDA-MB-231 cells proliferation with IC50 of 2.2 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    MX106 is a novel potent survivin inhibitor, effectively suppresses MDA-MB-231 cells proliferation with IC50 of 2.2 uM.
    MX106  significantly enhances the tumoricidal efficacy of doxorubicin in TNBC cells,.
    MX106  induces degradation of XIAP and/or cIAP1, which inhibited NF-κB activation by genotoxic agents.

    物理化学性质&存储条件

    分子量 390.527
    分子式 C25H30N2O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-(((4-isopropylbenzyl)oxy)methyl)-7-(pyrrolidin-1-ylmethyl)quinolin-8-ol

    参考文献

    1. Wang W, et al. J Pharmacol Exp Ther. 2018 May 7. pii: jpet.118.249151.

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