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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cdc2-like Kinase (CLK)-MW05
MW05

Chemical Structure : MW05

CAS No.:

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MW05 (CLK2/CLK4 inhibitor)

货号: PC-20894Not For Human Use, Lab Use Only.

MW05 is a specific inhibitor for DNA damage-induced NF-κB activity, inhibits CLK2 and CLK4 with IC50 of 1400 and 307 nM, does not inhibit CLK3.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    MW05 is a specific inhibitor for DNA damage-induced NF-κB activity, inhibits CLK2 and CLK4 with IC50 of 1400 and 307 nM, does not inhibit CLK3.
    MW05 selectively inhibits etoposide-induced p65 nuclear translocation with IC50 of 690 nM, without affecting p65 translocation upon TNFα stimulation.
    MW05 potentiates cell killing effects of chemotherapeutic agents, reduces cell viability and increases p53-mediated apoptosis in U2-OS cells.

    物理化学性质&存储条件

    分子量 363.42
    分子式 C20H21N5O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (3-amino-7-methoxy-3a,9a-dihydro-1H-pyrazolo[3,4-b]quinolin-1-yl)(3-(dimethylamino)phenyl)methanone

    参考文献

    1. Mucka P, et al. Cell Chem Biol. 2023 Jul 15:S2451-9456(23)00205-2.

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