MUT-A |CAS:1591906-37-4 Probechem Biochemicals

Chemical Structure : MUT-A

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MUT-A

货号: PC-61914Not For Human Use, Lab Use Only.

MUT-A is a novel potent, HIV-1 Integrase IN-LEDGF allosteric inhibitor, shows potent anti-HIV activity with EC50 of 32 nM and 12 nM for NL4-3 or HxB2 HIV-1 strains, respectively.

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生物&药学活性

MUT-A is a novel potent, HIV-1 integrase IN-LEDGF allosteric inhibitor, shows potent anti-HIV activity with EC50 of 32 nM and 12 nM for NL4-3 or HxB2 HIV-1 strains, respectively.
MUT-A interferes with the IN-LEDGF interaction during integration, shows no cellular toxicity in MT4 cells at 40 uM.
MUT-A inhibits IN (NL4-3)-LEDGF/p75 interaction with IC50 of 92 nM and promotes IN multimerization with activation constant AC50 of 55 nM.
MUT-A impairs virus maturation and infectivity but without influence on RNA packaging or virus immunoreactivity.

物理化学性质&存储条件

分子量	413.576
分子式	C24H31NO3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-(tert-butoxy)-2-(4-(4,4-dimethylcyclohex-1-en-1-yl)-2-methyl-5-(pyridin-4-yl)thiophen-3-yl)acetic acid

参考文献

1. Amadori C, et al. Retrovirology. 2017 Nov 9;14(1):50.

MUT-A

生物&药学活性

物理化学性质&存储条件

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MUT-A

生物&药学活性

物理化学性质&存储条件

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