MUS81 inhibitor 24

Chemical Structure : MUS81 inhibitor 24

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货号: PC-22697Not For Human Use, Lab Use Only.

MUS81 inhibitor 24 is a small molecule inhibitor of DNA repair endonuclease Mus81 with IC50 of 0.27 uM and SPR Kd of 1.1 uM (MUS81-EME1).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

MUS81 inhibitor 24 is a small molecule inhibitor of DNA repair endonuclease Mus81 with IC50 of 0.27 uM and SPR Kd of 1.1 uM (MUS81-EME1).
The Mus81 endonuclease resolves recombination intermediates and mediates cellular responses to exogenous replicative stress.

物理化学性质&存储条件

分子量	444.45
分子式	C24H20N4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4'-(2-cyanopiperazine-1-carbonyl)-[1,1'-biphenyl]-4-yl)-5-hydroxy-4-oxo-1,4-dihydropyridine-3-carboxylic acid

参考文献

1. Collie GW, et al. ACS Med Chem Lett. 2024 Jun 7;15(7):1151-1158.

2. Haiqing Fu, et al. Nat Commun. 2015 Apr 16:6:6746.