MU262 | MUS81 inhibitor | Probechem Biochemicals

Chemical Structure : MU262

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MU262 (MU-262)

货号: PC-26080Not For Human Use, Lab Use Only.

MU262 is a specific small molecule inhibitor of endonuclease MUS81 with IC50 of 0.87 uM in biochemical nuclease assay, inhibits MUS81-mediated DNA repair pathways in cells.

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生物&药学活性

MU262 is a specific small molecule inhibitor of endonuclease MUS81 with IC50 of 0.87 uM in biochemical nuclease assay, inhibits MUS81-mediated DNA repair pathways in cells.
MU262 has no negative effect on NHEJ, does not broadly suppress DNA repair but impair only HR/BIR pathways.
MU262 decreases BIR to the same extent as the siRNA-mediated depletion of MUS81, with an IC50 of 1.53 uM, also significantly reduces the efficiency of HR repair with IC50 of 0.5-1 uM.
MU262 likely impairs the MUS81 enzymatic activity through an alternative, DNA binding-independent mechanism.
MU262 significantly increases micronuclei formation in U2OS cells, similarly to the effect of MUS81 depletion.
MU262 induces persistent DNA damage leading to reduced cell survival, synergizes with cisplatin to reduce cancer cell viability.

物理化学性质&存储条件

分子量	374.38
分子式	C20H15FN6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(1H-Benzo[d]imidazole-2-yl)-7-ethyl-8-(4-fluorophenyl)pyrazolo[5,1-c][1,2,4]triazin-4-ol

参考文献

1. Prochazkova J, et al. J Med Chem. 2026 Feb 25. doi: 10.1021/acs.jmedchem.5c02096.

MU262 (MU-262)

生物&药学活性

物理化学性质&存储条件

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MU262 (MU-262)

生物&药学活性

物理化学性质&存储条件

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