MU1300 | CAS 2275602-42-9 Probechem Biochemicals

Chemical Structure : MU1300

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MU1300 (MU-1300;MU 1300)

货号: PC-35986Not For Human Use, Lab Use Only.

MU1300 (MU-1300) is novel effective, selective modulator of the Hedgehog (Hh) pathway, suppresses Hh-dependent osteogenesis with IC50 of 300 nM in osteoblast differentiation assay using C3H10T1/2 cells, targets and binds to Smoothened (Smo) directly.

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生物&药学活性

MU1300 (MU-1300) is novel effective, selective modulator of the Hedgehog (Hh) pathway, suppresses Hh-dependent osteogenesis with IC50 of 300 nM in osteoblast differentiation assay using C3H10T1/2 cells, targets and binds to Smoothened (Smo) directly.
MU1300 inhibited the GLI-mediated response with IC50 of 400 nM in GLI-dependent reporter gene assay using Shh-LIGHT2 cells.
MU1300 reduces the expression of the Hh target genes Gli1 and Ptch1 by 55% and 63% in NIH-3T3 cells in RT-qPCR analysis.
Only inhibits only 5 kinases to 40-60% at 10 uM in Thermo Fisher SelectScreen kinase panel (454 kinases).

物理化学性质&存储条件

分子量	300.376
分子式	C16H16N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-methyl-5-morpholino-7-(thiophen-3-yl)furo[3,2-b]pyridine

参考文献

1. Němec V, et al. Angew Chem Int Ed Engl. 2019 Jan 21;58(4):1062-1066.

MU1300 (MU-1300;MU 1300)

生物&药学活性

物理化学性质&存储条件

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MU1300 (MU-1300;MU 1300)

生物&药学活性

物理化学性质&存储条件

参考文献

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