MU1210 | CAS:2275601-87-9 Probechem Biochemicals

Chemical Structure : MU1210

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MU1210 (MU-1210;MU 1210)

货号: PC-35987Not For Human Use, Lab Use Only.

MU1210 (MU-1210) is a potent and highly selective inhibitor of cdc-like kinases (CLKs) with IC50 of 51 nM (cellular BRET for CLK1).

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生物&药学活性

MU1210 (MU-1210) is a potent and highly selective inhibitor of cdc-like kinases (CLKs) with IC50 of 51 nM (cellular BRET for CLK1).
MU1210 profoundly affected the Mdm4 alternative splicing and showed high activity in cytotoxicity assays using MCF7 breast cancer cells.
MU1210 has favorable pharmacokinetics (mouse, 10 mpk, IP: Cmax =1.24 mm, T1/2 = 58 min; no acute toxicity observed), suggesting its potential use in in vivo models; MU1210 is a quality probe for CLK1, CLK2, and CLK4.

物理化学性质&存储条件

分子量	352.397
分子式	C22H16N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-(1-methyl-1H-pyrazol-4-yl)-3-(3-(pyridin-4-yl)phenyl)furo[3,2-b]pyridine

参考文献

1. Němec V, et al. Angew Chem Int Ed Engl. 2019 Jan 21;58(4):1062-1066.

MU1210 (MU-1210;MU 1210)

生物&药学活性

物理化学性质&存储条件

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MU1210 (MU-1210;MU 1210)

生物&药学活性

物理化学性质&存储条件

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