MU-UNMC-2

Chemical Structure : MU-UNMC-2

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货号: PC-38237Not For Human Use, Lab Use Only.

MU-UNMC-2 is a potential small-molecule inhibitor of S-RBD and ACE-2 interaction, shows antiviral activity against SARS-CoV-2 with IC50 of 1.72 uM in human bronchial epithelial cells.

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生物&药学活性

MU-UNMC-2 is a potential small-molecule inhibitor of S-RBD and ACE-2 interaction, shows antiviral activity against SARS-CoV-2 with IC50 of 1.72 uM in human bronchial epithelial cells.
MU-UNMC-2 blocked the entry of pseudovirus particles expressing SARS-CoV-2 Spike glycoprotein.
MU-UNMC-2 effectively blocked the replication of rapidly transmitting variants of concern: South African variant B.1.351 Omicron (IC50=3.00 μM) and Scotland variant B.1.222 (IC50=1.39 μM).
MU-UNMC-2 displayed high synergy with remdesivir, the only approved drug for treating hospitalized COVID-19 patients.

物理化学性质&存储条件

分子量	285.24
分子式	C12H6F3NO2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(trifluoromethyl)benzo[b]thieno[2,3-f][1,4]oxazepin-10(9H)-one

参考文献

1. Arpan Acharya, et al. J Virol. 2021 Nov 23;95(24):e0143721.

2. Arpan Acharya, et al. bioRxiv. 2021 Apr 2;2021.04.02.438204.

MU-UNMC-2

生物&药学活性

物理化学性质&存储条件

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MU-UNMC-2

生物&药学活性

物理化学性质&存储条件

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