MTX-3937 | Siglec-9 inhibitor | Probechem Biochemicals

Chemical Structure : MTX-3937

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MTX-3937 (MTX3937)

货号: PC-21817Not For Human Use, Lab Use Only.

MTX-3937 is a small-molecule Siglec-9 inhibitor with binding KD of 3.15 uM in BLI assay, inhibits phosphorylation of Siglec-9 and downstream SHP1 and SHP2.

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生物&药学活性

MTX-3937 is a small-molecule Siglec-9 inhibitor with binding KD of 3.15 uM in BLI assay, inhibits phosphorylation of Siglec-9 and downstream SHP1 and SHP2.
MTX-3937 shows similar binding affinities towards Siglec-7 and Siglec-9.
MTX-3937 suppresses Siglec-9-induced inhibitory signaling and promotes NK cell functions, inhibits NK cell apoptosis.
MTX-3937 increases NK cell homeostasis, improves the functions and homeostasis of NK cells from patients with HCC or HBV.
MTX-3937 remarkably improves NK cell-mediated anti-tumor efficacy against liver cancer in vivo.

物理化学性质&存储条件

分子量	532.98
分子式	C33H21ClO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3'-(3-chlorophenyl)-5'-(p-tolyl)-3'H,5'H-dispiro[indene-2,2'-furan-4',2''-indene]-1,1'',3,3''-tetraone

参考文献

1. Xiao R, et al. J Hepatol. 2024 Feb 6:S0168-8278(24)00106-5.

MTX-3937 (MTX3937)

生物&药学活性

物理化学性质&存储条件

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MTX-3937 (MTX3937)

生物&药学活性

物理化学性质&存储条件

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