MTX-216 | Syk inhibitor | Probechem Biochemicals

Chemical Structure : MTX-216

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MTX-216 (MTX216)

货号: PC-49627Not For Human Use, Lab Use Only.

MTX-216 (MTX216) is a dual PI3K/EGFR inhibitor that blocks neurofibromin 1 loss of function (NF1LoF) melanoma cell growth in vitro and in vivo, suppresses the activity of SYK kinase with IC50 of 281 nM.

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生物&药学活性

MTX-216 (MTX216) is a dual PI3K/EGFR inhibitor that blocks neurofibromin 1 loss of function (NF1LoF) melanoma cell growth in vitro and in vivo, suppresses the activity of SYK kinase with IC50 of 281 nM.
MTX-216 at 1 μmol/L inhibited p-SYK expression in MeWo cells by approximately 50%, reduced p-BLNK levels in IgM-stimulated Ramos cells.
MTX-216 increases NF1LoF melanoma cells sensitivity to both PI3K and MEK inhibitors, suppresses genes that regulate mitochondrial ETC in NF1LoF cells.
MTX-216 effectively suppressed both Ki-67 and p-S6 in NF1LoF melanoma cells, inducing efficacious antitumor responses in these cells.

物理化学性质&存储条件

分子量	502.35
分子式	C22H14Cl2FN5O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-chloro-5-(4-((3-chloro-4-fluorophenyl)amino)-3-cyanoquinolin-6-yl)pyridin-3-yl)methanesulfonamide

参考文献

1. Cara Abecunas, et al. Cancer Res. 2023 Jan 18;83(2):316-331.

MTX-216 (MTX216)

生物&药学活性

物理化学性质&存储条件

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MTX-216 (MTX216)

生物&药学活性

物理化学性质&存储条件

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