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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-PI3K-MTX-211
MTX-211

Chemical Structure : MTX-211

CAS No.: 1952236-05-3

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MTX-211 (MTX 211, Mol 211)

货号: PC-70200Not For Human Use, Lab Use Only.

MTX-211 is a first-in-class, highly selective, dual inhibitor of PI3K and EGFR kinases with IC50 of <100 nM.

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10 mg ￥2580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MTX-211 is a first-in-class, highly selective, dual inhibitor of PI3K and EGFR kinases with IC50 of <100 nM.
MTX-211 demonstrated in vivo anticancer activity against multiple KRAS mutant colorectal tumors.
MTX-211 shows limited off-target toxicity and a broad therapeutic window.

物理化学性质&存储条件

分子量 478.323
分子式 C20H14Cl2FN5O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Methanesulfonamide, N-[2-chloro-5-[4-[(3-chloro-4-fluorophenyl)amino]-6-quinazolinyl]-3-pyridinyl]-

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